ea0042oc13 | (1) | Androgens2016
Nowakowska Karolina
, Riisnaes Ruth
, Rodrigues Daniel Nava
, Wetterskog Daniel
, Jayaram Anuradha
, Zaferiou Zafeiris
, Mateo Joaquin
, de Bono Johann S
, Attard Gerhardt
With the wide-spread use of abiraterone/enzalutamide for CRPC, there is an urgent need to understand and reverse resistance to these treatments. Studies have implicated glucocorticoid receptor (GR) as activating androgen receptor (AR) signalling and driving resistance. Here we studied progesterone receptor (PR), which is phylogenetically most closely related to the AR. We first used digital droplet PCR in prostate cancer (PCa) cell lines and observed >10 times higher level...